一、主要研究方向

1.复杂生物标志物的超灵敏定量检测

2.质谱探针设计、研发和应用

二、个人简历

2022年毕业于南京医科大学，获医学博士学位；同年于南京医科大学从事博士后研究；2025年加入蚌埠医科大学药物分析教研室，承担教学与科研工作。

三、主持科研/教学项目

        1.国家自然科学基金面上项目，22304085，级联信号放大纳米质谱探针集的构建及其超灵敏定量检测体液中痕量活性致病菌的临床研究，2023/01-2026/12，30万元，主持。

        2.中国博士后面上项目，2024M751496，信号放大纳米质谱探针的构建及其超灵敏检测血液中痕量活性致病菌，2024/07-2025/07，8万元，主持。

四、代表性成果

代表性论文：

1. Jianhua Zhu, Wenjun Zhang, Zhongcheng Wang, Yan Wang, Jiapu Li, Yunjing Wang, Feifei Xu, Yun Chen*. Mass-tagged self-assembled nanoprobe reveals the transport of PD-L1 from cancer cells to tumor-educated platelets. Analytica Chimica Acta, 2024, 1331:343312.

2. Jianhua Zhu^#, Yunfei Bai^#, Xiuyu Chen, Linlin Hu, Wenjun Zhang, Chunyan Liu, Hua Shao*, Jianguo Sun*, and Yun Chen*. Ultrasensitive detection of b-lactamase-associated drug-resistant bacteria using a novel mass-tagged probe-mediated cascaded signal amplification strategy. Chemical Science, 2022,13:12799-12807.

3. Xiaoxu Li^#, Bo Sun^#, Jianhua Zhu^#, Moting Qian, and Yun Chen*. Construction of a Mass-Tagged Oligo Probe Set for Revealing Protein Ratiometric Relationship Associated with EGFR−HER2 Heterodimerization in Living Cells. Analytical Chemistry, 2022,94:8838-8846.

4. Xiaoxu Li^#, Jianhua Zhu^#, Xiaoyu Shi, Zhongcheng Wang, Xi Chen, Xian Zhang, and Yun Chen*. Steric Hindrance On−Off Mass-Tagged Probe Set Enables Detection of Protein Homodimer in Living Cells. ACS Applied Materials & interface, 2022,14:54517-54526.